Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate
- VernacularTitle:醋酸曲安奈德巩膜植入剂的制备及体外释放特性考察
- Author:
Lei HU
;
Songqing LIU
;
Wei GUO
;
Qing DAI
;
Yunjia LIU
- Publication Type:Journal Article
- Keywords:
polylactic acid;
triamcinolone acetonide acetate;
uveitis;
scleral implant
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare a biodegradable sckeral implant containing triamcinolone-acetonide-acetate(TAA) and polylactic acid(PLA) and investigate its release in vitro.Methods The TAA-PLA implant was prepared by melt-extrude technique.The drug release of TAA in vitro was determined by high performance liquid chromatography(HPLC).Results The implant was white pillar with 8 mm in length,8 mg in weight,and 0.8 mm in diameter.The drug loading was 30%.The drug was released at a steady and slow rate.Its accumulation release rate is 75.84% on the 30th day.Drug release profile in vitro was in accordance with Higuchi equation Q=0.137(t-0.752)1/2.Conclusion A sleral implant containing TAA-PLA is prepared,which has the evident feature in delaying the release of TAA and is biological degradable.It might be a novel vehicle for the topical use of TAA.
