Research progress on the treatment of compensatory Congestive Heart Failure with recombinant human brain natriuretic peptide
- VernacularTitle:重组人脑钠肽治疗失代偿性充血性心力衰竭的研究进展
- Author:
Maiye ZHONG
;
Qiuhe JI
- Publication Type:Journal Article
- Keywords:
brain natriuretic peptide;
Congestive Heart Failure;
drug therapy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant human brain natriuretic peptide(rhBNP) is a synthetic peptide,its role is similar to endogenous brain natriuretic peptide,with effects on expanding blood vessel,diuretic,natriuretic,anti-sympathetic nervous system,decreasing plasma aldosterone and endothelin,also with characteristic of depress urization while neither speeding up the heart rate,nor activating the renin-angiotensin-aldosterone system.A number of studies had confirmed that recombinant human brain natriuretic peptide was effective in the treatment of Congestive Heart Failure(CHF),it could effectively improve the cardiac function,reduce the cardiac load and reverse left ventricular remodeling.It is now put on to market and applied in clinical treatment of Congestive Heart Failure.The article introduces rhBNP pharmacologic action,the relationship with CHF,and the research progress on the treatment of CHF.
