Research on evaluation methods of the fever syndrome model based on metabonomics
- VernacularTitle:基于代谢组学的热病证候模型评价方法研究
- Author:
Shumin LIU
;
Fang LU
;
Xijun WANG
;
Wenjun SUN
;
Peiliang DONG
- Publication Type:Journal Article
- Keywords:
metabonomics;
UPLC-Q-TOF/MS;
animal model;
evaluation method
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To establish a set of consummate evaluation methods of animal models which are with syndromes of traditional Chinese medicine.Method By means of 2,4-dinitrophenol-induced fever syndrome model for the entry point,making use of meta bonomics as the platform,through analyzing metabolic fingerprint data of rat urine in the control and model group and metabolome of rat urine in model group at different time intervals,to approach the evaluation methods of animal models.Results Through research by metabonomics,the results showed that 2,4-dinitrophenol-induced animal models consisted with clinical fever syndrome of traditional Chinese medicine.Conclusion Metabonomics can be used for evaluation studies of animal models which are with syndromes of traditional Chinese medicine.
