The RAGE-A? interaction and its effects on pathogenesis of Alzheimers disease
- VernacularTitle:晚期糖基化终产物受体与?-淀粉样蛋白的相互作用促进阿尔采末病的发展
- Author:
Weina KONG
;
Shengjun AN
;
Xiqing CHAI
- Publication Type:Journal Article
- Keywords:
Alzheimers disease;
?-amyloid protein;
receptor for advanced glycation end products
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Receptor for advanced glycation end products(RAGE) is a member of the immunoglobulin superfamily.In central nervous system,RAGE is mainly expressed by neurons,microglia,and cerebral endothelial cells.In Alzheimers disease(AD) brain,levels of RAGE are significantly increased from the positive feedback mechanisms driven by excess amounts of ?-amyloid protein(A?).The interaction of RAGE with A? in neurons,microglia,and cerebral endothelial cells induces the perturbation of neuronal functions,amplification of microglia inflammatory responses,and vascular dysfunction.Further understanding the molecular mechanisms associating RAGE-A? interaction provides us the opportunity to develop the therapeutic approaches for the devastating disease.
