The genes related with the osmotic expansion in sugar cataract
- VernacularTitle:糖性白内障渗透性膨胀期相关机制的研究进展
- Author:
Lixia JI
;
Zhufang SHEN
- Publication Type:Journal Article
- Keywords:
lens;
lens epithelial cell;
aldose reductose;
phospho-glycoprotein;
aquaporin
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Lens is a perfect optical organ,which roots in the surface ectoblast and has good quality of light penetration and refraction.It consists of lens bursa,epithelia,cortex and nucleus from exterior to interior in turn.The life center of lens is the epithelia which not only excretes collagen Ⅳ to form lens bursa outside,and gradually develops to fiber cell to form cortex and nucleus of lens,but also supports all the energy of lens metabolism.Aldose reductase can be activated by high glucose in a long time.Then,the sorbitol accumulation of lens epithelial cells and fibre cells causes cortex to absorb water and expand.Besides,some research results showed that p-glyprotein,clcn3(Cl-channel 3) and aquaporin were also involved in the high osmotic expansion of the lens.
