Research progress on topoisomerase Ⅰ inhibitors
- VernacularTitle:拓扑异构酶Ⅰ抑制剂研究进展
- Author:
Huixin TAN
- Publication Type:Journal Article
- Keywords:
topoisomerase Ⅰ;
inhibitor;
antitumor agent;
camp tothecin,non-camp tothecin topoisomerase I inhibitor
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Following the realization that involved in all of the key process within the cell nucleus such as DNA replication,transcription,reorganization,repair,human DNA topoisomerase Ⅰ(Topo Ⅰ) is a useful therapeutic target against tumor growth.Topo Ⅰ inhibitors represent a class of effective agents that have been extensively exploited and used for carcinomachemotherapy.Current Topo Ⅰ inhibitors being clinically used or developed are classified as campotothecins and non-camptothecins.This presentation introduces current status and trends of Topo Ⅰ inhibitors as anti-tumor agents with an emphasis on bioactive and pharmacological properties of these agents.
