ATP-sensitive potassium channel and its cardiovascular protection effects
- VernacularTitle:ATP敏感性钾通道及其心血管保护作用
- Author:
Rongyuan ZHANG
;
Hongfang JUN
;
Chaoshu TANG
;
Junbao DU
- Publication Type:Journal Article
- Keywords:
Potassium channels;
Adenosine triphosphate;
Cardiovascular system
- From:
Journal of Peking University(Health Sciences)
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of tissues and recognized as an important drug target.It connects cell metabolism with cell electric activity.KATP has been proposed to play protective roles during heart failure,arrhythmia,myocardial infarction,stress,myocardial ischemia and hypertension.In this review,a summary of KATP is presented with molecular structure,localization,regulation,cardiovascular protective effect and its mechanisms.
