Relationship of matrix metalloproteinase-9 expression and angiogenesis in lung carcinoma and its significance
- VernacularTitle:肺癌MMP-9表达与血管生成的关系及其意义
- Author:
Zhen QIN
;
Bin LUO
;
Xudong WANG
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
matrix metalloproteinase-9;
microvascular density
- From:Journal of Third Military Medical University
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of matrix metalloproteinase-9(MMP-9)expression and angiogenesis in lung carcinoma tissue and its significance.Methods Totally 84 patients were subjected,including 40 cases of lung squamous cell carcinoma,34 of lung adenocarcinoma and 10 of small cell lung cancer.Twenty samples of normal adjacent tissues served as control.The expression of MMP-9 and CD34 was detected in these 104 lung tissue samples by immunohistochemical method.The expression of MMP-9 was analyzed with clinical pathological data and microvascular density(MVD).Results The expression of MMP-9 in lung carcinoma tissues was significantly higher than that in para-cancerous normal lung tissues(P
