Experemental Study on the Effect of Whole Peptidoglycan of Bifid Bacterium in Inducing LoVo Cell Apoptosis in vitro
- VernacularTitle:双歧杆菌完整肽聚糖体外诱导大肠癌Lovo细胞凋亡的实验研究
- Author:
Zhanpeng QI
;
Liping WANG
;
Xianchun WEN
;
Jicheng LIU
- Publication Type:Journal Article
- Keywords:
Bifid bacterium;
Whole peptidoglycan;
Anti-tumor;
Inducing effect;
Early apoptosis
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the antitumor activities and mechanisms of bifid bacterial surface molecules,whole peptidoglycan(WPG).Methods First,large intestine cancer Lovo cell was cultured in vitro.Then,anti-proliferative effect and apoptosis inducing effect of WPG to LoVo cell were observed respectively by MTT assay and flow cytometry.Results In the group treated with WPG,the growth of LoVo cell was inhibited significantly in a dose-and time-dependent manner ;early apoptotic cells were greatly increased,and compared with the blank control group,a big difference existed(P
