The Clinical Study of Treating Skin T-lymphoma with Domestic Interferon(Sainuojin) and CHOPP-regimen
- VernacularTitle:国产干扰素(赛诺金)联合CHOPP方案治疗皮肤T细胞淋巴瘤的疗效观察
- Author:
Chengnong GUAN
;
Shujun LI
;
Liangzhen CAI
;
Qilian LIANG
- Publication Type:Journal Article
- Keywords:
Skin T-lymphoma;
CHOPP-regimen;
Interferon;
Sainuojin
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the curative effects and side-effects of combining low-dose domestic interferon(sainuojin)with CHOPP-regimen in treating skin T-lymphoma.Method During the period June 1996 to June 2008,46 cases patient with skin T-lymphoma were treated by low-dose domestic interferon(sainuojin)and CHOPP-regimen,and all patient were received four cycle chemotherapy at least.And the usage was as follows:Sainuojin 3?106U/d,im,d1～21;CTX 600mg/m2,iv,d1;ADM 50mg/m2,iv,d1;VCR 1.4mg/m2,iv,d1;Predinisone 90 mg/d,PO,d1～5;PYM 8mg/d,im,d1,3,5,and every 3 weeks repeat.At the same time,the place of skin lesion was daubed with hydrochloric acid nitrogen mustard once everyday.Results CR 23 cases,PR 16 cases,NC 7 cases.The effective rate was 84.78%.The maximum time of survivorship was 11.6 years;the average survivorship time was 8.9?0.56 years;and the mostly side-effects were arrest of bone marrow and fever.Conclusion The curative effects of combining low-dose domestic interferon(sainuojin)with CHOPP-regimen in treating skin T-lymphoma were confirmed,and the side-effects were small.It is good for clinical popularization and application.
