To Study the Protective Effect of Minocycline on the Model of the Cerebral Ischemia-reperfusion of Gerbils
- VernacularTitle:美诺环素对沙鼠脑缺血再灌注模型的神经保护作用机制研究
- Author:
Jianwen YANG
;
Zhiping HU
- Publication Type:Journal Article
- Keywords:
Cerebra;
Ischemia-reperfusion;
Minocycline;
Phosphoryla-tion P38MAPK
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect mechanism of minocyline on the model of the cerebral ischemia-reperfusion of gerbils by decreasing expression of phosphorylation P38MAPK.Methods A cerebral ischemia-reperfusion model in gerbils was established by clamping both common carotids.The ultrastructural alteration in pyramidal neuron in the hippocampal CA1 and the cortex of frontal lobe at different time was observed by electron microscope.And observe the expression level of phosphorylation P38MAPK by using immunohistochemistry technique.Results ①The damage to the neunos became more and more severe as gerbils survived longer postocclusion.Minocyline treated groups were lessened obviously.② Treatment with minocycline reduced expression of phosphorylation P38MAPK with a significant difference(P
