Effect of Glyceryl Trinatrate and Isosorbide Dinitrate Against Replication of Coxsackievirus B3 in vivo
- VernacularTitle:硝酸甘油和硝酸异山梨酯抗柯萨奇B组3型病毒感染的体内实验研究
- Author:
Yanying SUN
;
Fengxia DU
;
Meiling XIA
;
Yan SUN
;
Zhaohua ZHONG
- Publication Type:Journal Article
- Keywords:
Glyceryl trinatrate;
Isosorbide dinitrate;
Coxsackievirus B3;
Nitric oxide(NO);
Antivirus
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide an experimental evidence for the clinical applications of glyceryl trinatrate(GTN)and isosorbide dinitrate(ISDN)against Coxsackievirus B(CVB)-related myocarditis.Methods Coxsackievirus B3 was propagated in HeLa cells.Virus yields were determinded by 50% tissue culture infective dosage(TCID50).BALB/c mice were attacked with 5000 TCID50 of CVB3,meanwhile,the mice were administrated with GTN and ISDN.All mice were killed at the 14th day.The myocardial tissues were harvested for histologic evaluation.Results The infection plaques in the myocardial tissues obtained from CVB3-infected BALB/c mice treated with GTN were siginificantly reduced(0.89?0.18 in GTN group and 1.25?0.22 in ISDN group)compared with that of the untreated CVB3-infected mice(P
