Effects of Heying Anxin Fang on cardiac function and intracellular Ca~(2+) concentration in cadiocyte of chronic congestive heart failure rats
- VernacularTitle:和营安心方对慢性心衰大鼠心功能及心肌细胞内钙离子浓度的影响
- Author:
Yongmin LI
;
Baohe WANG
;
Jin HE
;
Xinsheng WANG
;
Hua LIU
- Publication Type:Journal Article
- Keywords:
Heyinganxin Fang;
Congestive heart failure;
Calciumion;
Cardiac function;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the e ects of Heying Anxin Fang on cardiac function and intracellular Ca2+ concentration in cadiocyte of chronic congestive heart failure rats. Methods: Animal models of heart failure were induced by subcutaneous injection of a large dose of ISO, and were randomly divided into model group, Shenmai injection group, captopril group, high, middle and low dosages of Heyinganxin Fang group and normal group with 9 in each group. To determine the indexes of LVSP, LVEDP, +dp/dtmax ,-dp/dtmax and heart weight, and determine Ca2+ concentration in cardiomyocytes by ow cytometer. Results: Compared with normal group, the indexes of heart weight, Ca2+ concentration and LVEDP in model group increased, but indexes of LVSP, +dp/dtmax, -dp/dtmax decreased obviously(P
