Effect of polysaccharide ingredients from TCM complex prescription on releasing cytokines of mouse peritoneal macrophages
- VernacularTitle:四物汤等复方多糖组分对小鼠腹腔巨噬细胞释放细胞因子的影响
- Author:
Weiyi TIAN
;
Juan YANG
;
Ping WANG
;
Wenjia WANG
- Publication Type:Journal Article
- Keywords:
TCM compound prescription;
Polysaccharide ingredient;
Cytokine;
Macrophage;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of polysaccharide ingredients from six TCM complex prescriptions on releasing the cytokine(CK) level of mouse celiac macrophages (M?), to explore the possible mechanism and direct the extractionand separation of active components for above compounds. Methods: The total polysaccharide ingredients of six complex prescriptions were prepared: Siwu Decoction, Sijunzi Decoction, Liuweidihuang Decoction, Guizhi Decoction, Longdanxiegan Decoction and Yupingfeng Pulveres, then the mouse celiac M? were incubated together in 96 holes board. Furthermore, levels for the latter to release CK, including IL-1?, IL-6, IL-8 and TNF-?, were measured. Results: Polysaccharide ingredients of each complex prescription could obviously accelerate mouse celiac M? to release one or more CK, and the e ects had concentration otherness (P
