The Correlation of Bone Mineral Density with Plasma Klotho Levels and Its Related Factors in Type 2 Diabetic Patients
- VernacularTitle:2型糖尿病患者骨密度改变与血浆klotho水平及其相关因素的关系
- Author:
Danfeng LAN
;
Ling WANG
;
Yuming WANG
;
Dianping SONG
;
Qiuping YANG
- Publication Type:Journal Article
- Keywords:
Bone mineral density;
Klotho protein;
Diabetes mellitus Type 2
- From:
Journal of Kunming Medical University
2013;(8):28-30,50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of bone mineral density (BMD) with plasma Klotho levels and its related factors in type 2 diabetic patients (T2DM) . Methods BMD was measured by Dual-energy X-ray absorptiometry (DEXA) in 159 T2DM patients. The patients were divided into three groups:normal bone mass, reduced bone mass and osteoporosis. The fasting plasma levels of Klotho were detected in these patients using enzyme linked immuno sorbent assay (ELISA), clinical and biochemical parameters also were tested, the difference and related factors were compared and analyzed in each group. Results Plasma Klotho levels were not significantly different among the three groups (4.95±0.48 vs 4.96±0.47 vs 4.91±0.49,P>0.05) . BMD at the first, second, third, fourth and total lumbar spine, femoral neck, trochanter and total body were not associated with plasma Klotho levels in these patients (P>0.05) . Age, diabetic duration, HDL-C and BMI were independent determinants for BMD in T2DM patients. Conclusions BMD might be not associated with plasma Klotho level in T2DM patients. But age,diabetic duration,HDL-C and BMI are associated with reduced BMD and osteoporosis in T2DM patients.
