Effects of Trifoliumpratense Leguminosae extract on mouse allogenetic skin transplantation
- VernacularTitle:红车轴草提取物对小鼠同种异基因皮片移植的影响
- Author:
Zhi YANG
;
Xiuyan HUANG
;
Jingfang DI
;
Yaoying ZENG
- Publication Type:Journal Article
- Keywords:
TLE;
Skin transplantation;
Allogene;
Proliferation;
Mixed lymphocyte reaction;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of Trifoliumpratense Leguminosae extract (TLE) on mouse allogenetic skin transplantation. Methods: Recipient BALB/c was divided into physiologic saline (PS) group and TLE group, full-thickness skins were transplanted through back to back method from donor C57BL/6. The allogenetic transplanted skin growth condition was observed. The proliferation of lymphocytes of recipient mice in vitro were detected by CFDA-SE stain and mixed lymphocyte reaction respectively. Results: The allogenetic transplanted skin injected with TLE 25g/kg per day by vena caudalis growed better than that in PS group. The proliferation of lymphocyte in TLE group was smaller than that in PS group. Conclusion: TLE maybe participate in the regulation of mouse immune system and induce its tolerance to the allogenetic transplanted skin.
