Study on inhibition mechanism of Tongbiling Composition on neovascularization
- VernacularTitle:通痹灵合剂抗新生血管形成机制的研究
- Author:
Juan TONG
;
Guangxing CHEN
;
Qingping LIU
;
Jifan CHEN
- Publication Type:Journal Article
- Keywords:
Arthritis;
Tongbiling Composition;
VEGF;
New vessels
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The study was to reveal the inhibition of neovascularization by Tongbiling. Methods: Rat model were established by injecting CFA at the root of the tail and divided into model control group, Indomethacin group and Tongbiling group at random. The serum and paws were collected after seven days treatment. 10ng/L VEGF solution was added I into CAM to stimulate the neovascularization, and to observe the influence of each group of serum on the first and second order new vessels. RT-PCR method was taken to determine the expression of mRNA of VEGF and VEGFR-1 of paws in different groups. Results: The number of vessels in the model control group was significantly more than that in the Indomethacin group and the Tongbiling group (P
