Changes in serum PAI-1,TF and ATⅢ in severe limb injury and their relationship with complications
- VernacularTitle:四肢严重创伤患者PAI-1、TF、ATⅢ水平变化及与并发症的相关性研究
- Author:
Jun LAI
;
Xiankai HUANG
;
Ning KANG
;
Cheng PENG
- Publication Type:Journal Article
- Keywords:
wounds and injuries;
extremities;
thromboplastin;
antithrombin Ⅲ;
plasminogen activator inhibitor 1
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes in serum plasminogen activator inhibitor 1(PAI-1),tissue factor(TF) and antithrombin Ⅲ(ATⅢ) in early period of severe limb injury,and their relationship with the occurrence of traumatic pre-DIC and DIC after trauma.Methods Thirty-five patients were divided into severe injury group(AIS score ≥3,20 cases),minor injury group(15 cases),and 10 healthy subjects served as control.The 35 patients with injury were divided again into pre-DIC group(10 cases),DIC group(3 cases),and others(22 cases).Fasting peripheral venous blood was collected on day 1,3,6 from the patients and healthy subjects.The changes in TF,ATⅢ and PAI-1 levels were detected and statistically analyzed.Results The PAI-1 levels were higher in minor injury group and severe injury group than that in control group on day 1(P
