Effects of Bacille Calmette Guerin on immunological function of infants with bronchiolitis
- VernacularTitle:卡介苗对毛细支气管炎患儿免疫功能的影响
- Author:
Hui HUANG
;
Yali LIU
- Publication Type:Journal Article
- Keywords:
bronchiolitis;
Bacille Calmette-Guerin;
IL-4;
IL-10;
IL-12
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To approach the effects of Bacille Calmette-Guerin(BCG)on immunological function of infants with bronchiolitis in vitro. METHODS: The monocytes were segregated from the peripheral blood of infants with acute bronchiolitis and healthy infants as control. The cytokines of IL-10 and IL-12 were measured by ELISA after interfered with different concentrations of BCG in vitro. IL-4, produced by lymphocytes treated with the cultural supernatant of BCG-stimulated monocytes were determined by ELISA. Acute bronchiolitis infants and health children treated with normal saline were as control. RESULTS: BCG stimulated IL-10 and IL-12 production in a dose response manner in a certain concentration range. The higher level of IL-10 was observed when BCG concentration reached 50 ?L/mL, while IL-12 had no significant increase. The level of IL-4 was markedly decreased compared with pre-treatment (P
