Gender difference in activation of platelets in septic rats
- VernacularTitle:性别差异对脓毒症大鼠血小板活化的影响
- Author:
Jinyu HU
;
Jinbao LI
;
Xiaoming DENG
- Publication Type:Journal Article
- Keywords:
blood platelets;
sepsis;
gender factors;
estrogens
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence of gender difference on the activation of platelets in septic rats.Methods: Totally 20 female and 20 male SD rats were randomly divided into four groups: male sham-operated group,female sham-operated group,female septic group,and male septic group,with each group containing 10 rats.Sepsis model in the last two groups was produced by cecal ligation and puncture(CLP);rats in the sham-operated group received no CLP.The rats were sacrificed 24 hours after surgery;the blood samples were collected for blood routine test;and the serum ?-TG levels were detected by ELISA assay.Serum estrogen(E2) levels were detected by radioimmunoassay.Results: The blood platelet counts were decreased in both septic rats of both genders;the count in female rats was significantly higher than in the male rats(P
