Endostatin:antiangiogenic properties and the therapeutic effect on rheumatoid arthritis
- VernacularTitle:内抑素抗血管生成及抗类风湿性关节炎治疗
- Author:
Xueying HUANG
;
Feihu CHEN
;
Xiaoming ZHANG
;
Yongjing LIU
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
neovascularization;
endostatin;
vascular endothelial growth factor
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Neovascularization is one of the early pathologic changes of rheumatoid arthritis(RA)synovium and is the major players in the promotion and perpetuation of pannus.Endostatin has antiangiogenic effect via inhibition of endothelial cell proliferation,migration and induction of apoptosis.The inhibition of angiogenesis in synovium by endostatin appears to be a promising means for the future treatment of RA.Also,endostatin has a therapeutic effect on RA by the inhibition of proliferation and induction of apoptosis in fibroblast-like synoviocytes.
