Effect of CYP3A5~*3 and CYP3A4~*18B genetic polymorphisms on cyclosporine pharmacokinetics in renal transplant patients
- VernacularTitle:CYP3A5~*3和CYP3A4~*18B基因多态性对肾移植患者环孢素药代动力学的影响
- Author:
Yongfang HU
;
Suodi ZHAI
;
Wen QIU
- Publication Type:Journal Article
- Keywords:
single nucleotide polymorphisms;
CYP3A5;
CYP3A4;
cyclosporine;
transplantation
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate retrospectively the effect of genetic polymorphisms in CYP3A4 and CYP3A5 on cyclosporine pharmacokinetics during the early period in renal transplant patients.Methods Polymerase chain reaction-restriction fragment length polymorphism was performed to genotype for CYP3A4*18B and CYP3A5*3.Cyclosporine whole blood levels were measured by fluorescence polarization immunoassay.Results The frequencies of CYP3A4*18B and CYP3A5*3 variant alleles were 0.235(95 CI:0.235~ 0.241)and 0.770(95 CI:0.767~0.773),respectively in 63 of renal transplantation patients, and these alleles exhibited incomplete linkage disequilibrium. The median (range) value of cyclosporine dose adjusted blood trough concentrations (C0/D) and C0 in CYP3A4*1/*1 genotype patients was higher than that in CYP3A4*1/*18B and CYP3A*18B/*18B patients, the same result was found in CYP3A5 expression (CYP3A5*3/*1 and CYP3A5*1/*3) (P
