The effect of pinacidil ischemic postconditioning protects against myocardial injury in rats
- VernacularTitle:吡那地尔缺血后处理对大鼠心脏的保护作用
- Author:
Xiaoyan DONG
;
Fen ZHU
- Publication Type:Journal Article
- Keywords:
myocardial stunning;
anoxia-reperfusion injury;
pinacidil ischemic postconditioning
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effect of pinacidil ischemic postconditioning on rat ventricular myocytes during ischemia/reperfusion.Methods Rat acute myocardical anoxia-reperfusion model was used.The cardiac function and electrophysiological properties were surveyed by isolated perfusion and patch-clamp technique,respectively.Results Compared with those in the control groups,these results demonstrated that anoxia-reperfusion groups in rats could increase PSP and-dp/dtmax markedly while LVDP,+dp/dtmax and HR decreased slightly.Significant difference was found in A/R group;while pinacidil group showed the better recovery of cardiac function after ischemia/reperfusion. using patch-clamp technique,significant difference was found in pinacidil group,including increasing mean open time and conductance value.Conclusion Ischemic postconditioning by Pinacidil(PCOS of KATP)exerts an cardioprotection effect on acute myocardial anoxia-reperfusion injury.
