Matrine Compoand Injection Interrening the Liver Fibrosis Rat Induced by Tetrachloride.
- VernacularTitle:复方苦参碱干预大鼠四氯化碳诱导的肝纤维化的作用观察
- Author:
Jinhua YU
;
Chunhui SONG
;
Guofeng CHEN
- Publication Type:Journal Article
- Keywords:
Matrine compound injection;
Liver fibrosis;
Rats;
TGF-?1
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the change of TGF-?1 in the bloods of rats which were induced by tetrachoride during the different times and to explain the mechanism of the change.MethodsThe experimental liver fibrosis induced by tetrachloride in rats was treated by matrine compound injection.Serum TGF-?1 and pathological changes in liver tissue were observed in control group,model group and therapy group during the time of the 4th,6th and 9th week.ResultsThere was an obvious change of TGF-?1 in the blood in different time and different groups.ConclusionMatrine compound injection has an antifibrogenetic action and TGF-?1 can reflect the change of liver fibrogenesis of different time as an index.
