A Randomized Clinical Study:Concurrent Chemoradiotherapy Combined with Consolidation or Induction Chemotherapy for Locally Advanced Non-small Cell lung Cancer.
- VernacularTitle:局部晚期非小细胞肺癌同步放化疗联合巩固化疗或诱导化疗的随机临床研究
- Author:
Zhen ZHANG
;
Shuhong HAN
;
Xiaotao ZHANG
;
Xuezhen MA
- Publication Type:Journal Article
- Keywords:
Neoplasm;
Non-small cell lung/three-dimensional conformal radiotherapy;
Neoplasm,non-small cell lung/chemotherapy;
Concurrent chemoradiotherapy;
Locally advanced;
Consolidation chemotherapy;
Induction chemotherapy.
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and the side-effects of concurrent chemoradiotherapy combined with consolidation or induction chemotherapy for locally advanced non-small cell lung cancer(NSCLC).Methods64 patients with stage ⅢA and ⅢB NSCLC were divided randomly into the CCT group(concurrent chemoradiotherapy followed by consolidation chemotherapy) and the ICT group(induction chemotherapy followed by concurrent chemoradiotherapy).All patients were deliverd to thoracic planning target with total dose of 54~66Gy(median dose 60Gy)in 6~7 weeks.CCT group started to irradiate by conformal radiotherapy technique on day 1,and ICT started on day 43 with single fraction dose 200 cGy and 5 fractions every week.ResultsThe response rate in CCT and ICT group was 60.0% and 58.8% respectively(P=0.924),with no statistic significance between the CCT and ICT group.The side-effects were mainly granulo-cytopernia,radiation espohagitis and radiation pneumonitis.ConclusionConcurrent chemoradiotherapy combined with consolidation or induction chemotherapy for locally advanced NSCLC is well tolerated.The sequence of adjuvant chemothreapy to concurrent chemoradiotherapy produced no significant difference for NSCLC in recent response.
