Expression of S100 and MMP-7 in the Perineural Invasion of Cholangiocarcinoma and Their Clinical Significance
- VernacularTitle:S100与MMP-7在胆管癌神经浸润转移中的表达及意义
- Author:
Kun TANG
;
Xiaofang LIU
- Publication Type:Journal Article
- Keywords:
Cholangiocarcinoma;
Perineural invasion;
S100;
MMP-7;
Immunohistochemistry
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of S100 and MMP-7 in human cholangiocarcinoma and their correlation with the perineural invasion of cholangiocarcinoma.MethodsThe expression of S100 and MMP-7 in 36 cases of human cholangiocarcinoma tissues and edjunct cancer tissues were analyzed by immunohistochemistry method,combining with the clinical documents analysis.ResultsThe positive rates of S100 and MMP-7 in 36 cases of human cholangiocarcinoma were 61.11%(22/36) and 83.33%(30/36),respectively,while in edjunct cancer tissues were 30.56%(11/36),0.0%(0/36).The positive rate of Hematoxylin and Eosin staining indicated perineural invasion was significantly correlated with S100(P0.05).There was a significant positive correlation between S100 and MMP-7(P
