The Effects of Naoyi'an on the Expression of ICAM-1 in the Brain of Rats with Experimental Intracerebral Hemorrhage
- VernacularTitle:实验性脑出血大鼠脑内ICAM-1表达及脑溢安的保护作用
- Author:
Yihui ZHI
;
Xingqun LI
;
Tong LI
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
ICAM-1;
Naoyi'an;
rats
- From:
Journal of Zhejiang Chinese Medical University
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effects of Naoyi'an (NYA) on the expression of ICAM-1 in the brain of rats with experimental intracerebral hemorrhage.[Methods] The rats model of intracerebral hemorrhage was prepared by type Ⅶ collagenase injected into globus pallidus under stereotaxic apparatus.Then,the expression of ICAM-1 with or without intervention with NYA was determined in the brain of these animals respectively by in situ hybridization and western blot technique.[Results] Among the modeling animals,the expression of ICAM-1 was increased after the operation.In contrast,the expression of ICAM-1 was significantly down-regulated in the rats treated by NYA(P
