Effect of antidepressant on behavior and vascular endothelial cell growth factor in hippocampus of rat model of depression
- VernacularTitle:抗抑郁药物促进抑郁模型大鼠行为和海马血管内皮细胞生长因子的表达
- Author:
Xuemei LI
;
Li KUANG
- Publication Type:Journal Article
- Keywords:
depression;
hippocampus;
fluoxetine;
tianeptine;
vascular endothelial cell growth factor
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the mechanism by which antidepressant works on vascular endothelial cell growth factor(VEGF) in rat hippocampus of depression model.MethodsForty SD rats were randomly and equally divided into 5 groups: stress+fluoxetine,stress+tianeptine,stress,stress+normal sodium,blank matched control.We adopted separation and chronic unpredicted mild stress to establish depression in all rats except those in blank matched control group,and the behavior of all animals was evaluated by open-field and fluid consumption test.VEGF expression was detected by immunohistochemisty after intragastric administration respectively with fluoxetine,tianeptine or normal sodium for 30 d.ResultsVEGF expression in hippocampus was decreased in all stress groups compared with control group(P
