Regulatory effects of PARG on PARP in colorectal carcinoma
- VernacularTitle:大肠癌中聚(腺苷二磷酸核糖)水解酶对聚(腺苷二磷酸核糖)聚合酶的调节作用及意义
- Author:
Jia LI
;
Ling LIN
;
Yalan WANG
- Publication Type:Journal Article
- Keywords:
Poly(ADP-ribose) glycohydrolase;
Poly(ADP-ribose) polymerase;
colorectal carcinoma
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between Poly(ADP-ribose) glycohydrolase(PARG) and Poly(ADP-ribose) polymerase(PARP) in colorectal carcinoma.MethodsImmunohistochemical S-P staining was used to examine the expressions of PARG and PARP in 44 specimens human colorectal carcinoma.The positive rate of PARG and PARP in murine colon carcinoma CT26 cells was detected by flow cytometry before and after the treatment of PARG inhibitor Gallotannin.ResultsPARG and PARP expressed in colorectal carcinoma specimens was of positive correlation(r=0.300 01,P
