Effects of ?-3 polyunsaturated fatty acids on bone biomechanics in ovariectomized rats
- VernacularTitle:?-3多不饱和脂肪酸对去卵巢大鼠骨生物力学的影响
- Author:
Ping XU
;
Rong MA
;
Xiaoxia CHANG
;
Jie WU
;
Qingxin ZHAI
;
Xiaozhi SHEN
;
Baorui LIU
- Publication Type:Journal Article
- Keywords:
?-3 PUFAs;
Ovariectomized rats;
Bone biomechanics;
Osteoporosis
- From:
Parenteral & Enteral Nutrition
1997;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the benefit effects of ?-3 polyunsaturated fatty acids on bone biomechanics in ovariectomized(OVX) rats.Methods: 60 virgin female Sprague-Dawley rats were randomized by the stratified weight method into 6 groups: ① Sham group:deionized water 2 mL/d;②OVX group:deionized water 2 mL/d;③E2 group: OVX +17?-ethinylestradiol 0.1 mg/(kg?d);④ A group: OVX+?-3 PUFAs 75 mg/(kg?d);⑤B group: OVX+?-3 PUFAs 150 mg/(kg?d);⑥ C group: OVX+?-3 PUFAs 300 mg/(kg?d).Each group had 10 rats.After feeding for 90 days,the rats were killed and femur were separated.The maximum load,maximum deformation,elastic load,elastic deformation and energy absorption were measured from three point bending test.Bone wet weights were measured.Result: The femur biomechanics markers of OVX group decreased obviously,while that of all medicated group increased obviously(P
