The effects of alanyl-glutamine dipeptide-enriched parenteral nutrition on outcome in radiation enteritis rats
- VernacularTitle:谷氨酰胺双肽对放射性肠炎大鼠结局的影响
- Author:
Guanglong DONG
;
Xiaonan LIU
;
Zhang ZHANG
;
Yun ZHANG
;
Boquan JIN
- Publication Type:Journal Article
- Keywords:
Alanyl-glutamine;
Radiation enteritis;
Parenteral nutrition;
Rats
- From:
Parenteral & Enteral Nutrition
1997;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of alanyl-glutamine(Ala-Gln) on outcome in radiation enteritis rats.Methods: Male SD rats(n=70)were separated randomly into four groups: control group(n=10),AR+pseudosurgery group(n=20),AR+TPN group(n=20) and AR+TPN+Ala-Gln group(n=20).Rats were observed for mortality,changs of body weight,villous hight and area,the bcteriral translocation(BT)in mesenteric lymph nodes(MLNs),liver,spleen and peritoneal cavity.Serum TNF-? and sIL-2R level were determined by sandwich ELISA.Results: When Ala-Gln was administered in radiation enteritis rat,the mortality,body weight loss and bacterial translocation were decreaded,the villous hight and area was increased and the TNF-? and sIL-2R levels were reduced.Conclusion: Parenteral Ala-Gln nutrition can improves the results of radiation enteritis rats.
