Effect of Biqi capsule on human cartilage glycoprotein-39 in peripheral blood monouclear cells in rheumatoid arthritis
- VernacularTitle:痹祺胶囊对类风湿关节炎外周血单核细胞人类软骨糖蛋白39的影响
- Author:
Wei LIU
;
Xiaoya LIU
- Publication Type:Journal Article
- Keywords:
Biqi capsule;
RA;
PBMC;
HCgp-39
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Biqi capsule on human cartilage glycoprotein-39 in peripheral blood monouclear cells,research the possible mechanism of Biqi capsule.Methods: 39 patients with RA and 10 healthy people were selected.Expression levels of human cartilage glycoprotein-39(HCgp-39) mRNA in peripheral blood monouclear cells(PBMC) were detected by Rt-PCR method.Results: Obvious expression of HCgp-39 mRNA was found in patients with RA,the relative expression quantity was(0.7920?0.5240),which has a signifi cant difference(0.3104?0.2519,P=0.024) compared with the healthy controls;expression levels of the HCgp-39 mRNA after treatment were signifi cantly decreased,there were statistically signifi cant differences(0.4755?0.2431,P=0.038) between pre and post treatment.Conclusions: The HCgp-39 mRNA in PBMC of patients with RA were obviously higher than that of healthy ones.These data supported a correlation between the activity of RA and the HCgp-39 mRNA in PBMC;there was a certain fall in the expression levels after treatment,which hinted the immunological regulation of Biqi capsule.
