Study on adscription of plasma effective constituents of rat after administrated with alkaloid fraction of Nelumbo nucifera
- VernacularTitle:荷叶生物碱部位大鼠血中移行成分的初步研究
- Author:
Hao WU
;
Bin LIU
;
Wei WANG
;
Renbing SHI
;
Yuxia WANG
- Publication Type:Journal Article
- Keywords:
Nelumbo nucifera;
Alkaloid fraction;
Effective constituents;
HPLC
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the adscription of plasma effective constituents of rat after oral administration of alkaloid fraction of Nelumbo nucifera.Methods: Based on the established HPLC analytical method of plasma effective constituents,analysis and comparison were carried out among HPLC profi les of plasma samples obtained after oral administration of alkaloid fraction of Nelumbo nucifera,blank plasma,alkaloid fraction of Nelumbo nucifera.Results: Sixteen compounds were detected under the method,three of them were architypes of compound contained in alkaloid fraction of Nelumbo nucifera,and the others were metabolites.Through the comparison of the UV spectra,seven metabolites remain essential structure because the max wavelength was same to the architypes’,the other six metabolites’ structure changed greatly.Conclusion: Through the study of the adscription of plasma effective constituents of rat after oral administration of alkaloid fraction of Nelumbo nucifera,the structure of metabolites can be conjectured,which may be helpful to study the ADME and mechanism of action.
