Effects of Chelators on Liver Cadmium Contents in Chronic Cadmium Intoxication Rats.
- Author:
Suk Ho LEE
;
Kyu Taek LEE
;
Joon Hyoek LEE
;
Jong Kyun LEE
;
Poong Lyul RHEE
;
Jae Jun KIM
;
Kwang Cheol KOH
;
Seung Woon PAIK
;
Jong Chul RHEE
;
Kyu Wan CHOI
- Publication Type:Original Article
- Keywords:
Chelators;
Cadmium (Cd) contents;
Liver
- MeSH:
1-Propanol;
Animals;
Cadmium Chloride;
Cadmium*;
Calcium;
Characidae;
Chelating Agents*;
Edetic Acid;
Human Body;
Humans;
Injections, Intraperitoneal;
Kidney;
Liver*;
Male;
Metals, Heavy;
Penicillamine;
Poisoning;
Propane;
Rats*;
Rats, Sprague-Dawley;
Sodium;
Soil;
Succimer;
Succinic Acid
- From:The Korean Journal of Hepatology
1998;4(1):59-68
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The heavy metals like cadmium (Cd) are neither destroyed nor produced in human body and may infiltrated into air, water, soil, food, human body and redistributed by biological and geographical circulation. With advent of recent industrialization detrimental heavy metal poisoning in human body is increased by industrial pollution. We aimed to establish the relative abilities of chelators to mobilized liver cadmium contents in chronic cadmium intoxication rats. METHODS: Sprague-Dawley albino male rats weighing 200 to 250 mg were used. All animals were loaded with 3 intraperitoneal injections of cadmium chloride (1.5 mg/kg) given at % hourly interval. Intraperitoneal injection of chelators commenced 1 week after the last loading injection and continued every 72 hour for a total of 10 injections. Chelators were given at a level of 1 mmole/kg (except 0.01 mmol/kg of BAL). The chelators used in present experiment are 1,2-diaminocyclohexane tetra acetate (CDTA), disodium calcium ethylene diamine tetra acetate (EDTA), sodium 2.3-dimer capto propane sulfonate (DMPS), sodium di ethyl dithio carbamate (DDTC), dimercapto succinate (DMSA), 2,3-dimer capto propanol (BAL), diethylene triamine penta acetate (DTPA), triethylene tetr amine hexa acetate (TTHA), D-penicillamine(DPA), Nacetyl penicillamine (NAPA). RESULTS: 1) The residual liver cadmium content was reduced in rats administered DPA, EDTA, NAPA, CDTA, DDTC and DMSA (32%, 23%, 19%, 17%, 16% and 15% respectively) compared with control group. 2) The residual kidney cadmium content was reduced in rats administered DPA, DDTC, CDTA and EDTA (33%, 21%, 18% and 17% respectively) 3) The summation of residual cadmium content in liver and kidney was reduced in rats administered DPA, EDTA, DDTC and CDTA (33%, 20%, 18% and 17% respectively) compared with control group. CONCULUSIONS: We suggested that DPA, EDTA, CDTA and DDTC might have protective role against the toxic effects of cadmium.
