THE HEPATOPROTECTIVE EFFECT OF OAT ?ETA-GLUCANS ON LIVER INJURY IN HYPERLIPEMIA RATS
- VernacularTitle:燕麦?-葡聚糖对高脂血症大鼠肝损伤的保护作用
- Author:
Suping PEI
;
Wenjun MAI
;
Hao SUN
;
Ying WANG
;
Li MA
- Publication Type:Journal Article
- Keywords:
oat ?-glucans;
hepatoprotective effect;
liver injury;
chitosan oligosaccharide
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of oat ?-glucans on liver injury in hyperlipemia rats.Method Rats were fed on high fat forage for 3 w to establish hepatic injury model,then the model group was orally given oat ?-glucans at doses of 133,266 and 533 mg/(kg bw.d) respectively.At the same time,there were 3 control groups including 200 mg/(kg bw.d) chitosan oligosaccharide,normal and liver injury(model group fed with distilled water).Serum levels of ALT and AST,the content of MDA in serum and liver homogenate was assayed.Results Oat ?-glucans at high dose obviously decreased the levels of ALT,AST and MDA in the liver injury models,SP had a better protective effect on the liver injury than oligosaccharide did.Besides,in the treated group with ?-glucans,degenerative and necrotic changes of the liver cells were apparently milder than those of the untreated group.Conclusion Oat ?-glucans can obviously relieve the liver injury in hyperlipemia rats.
