Protectve effects of recombinant human tumor necrosis factor receptor:Fc fusion protein on acute lung injury induced by lipopolysaccharide in rats
- VernacularTitle:重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白对脂多糖致大鼠急性肺损伤的保护作用
- Author:
Shiting WANG
- Publication Type:Journal Article
- Keywords:
lipopolysaccharide;
acute lung injury;
TNF-?;
protection effects of rhTNFR:Fc
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the mechanisms and protective effects of recombinant human tumor necrosis factor receptor :Fc fusion protein(rhTNFR:Fc)on the acute lung injury induced by lipopo1ysaccharide(LPS)in rats.METHODS:The rat model of acute lung injury was established with LPS and the rats were randomly divided into four groups:control group,rhTNFR:Fc group,LPS group and rhTNFR:Fc+LPS group.After administration,the rats' death was recorded,the pulmonary wet/dry weight ratios were determined,the changes of lung histopathology were observed by HE dyeing,the levels of TNF-? and the bioactivity in serum were detected.RESULTS:Compared with control group the rats' mortality rate and pulmonary wet/dry weight ratio were significantly higher in the LPS group(P
