Progress in treatment of autosomal dominant polycystic kidney disease
- VernacularTitle:常染色体显性遗传多囊肾病的治疗研究进展
- Author:
Jinsheng GAO
;
Baoxue YANG
- Publication Type:Journal Article
- Keywords:
ADPKD;
treatment of PKD;
polycystin;
suppression of cell growth;
inhibition of cyst fluid secretion
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Autosomal dominant polycystic kidney disease(ADPKD),a common inherited disease,is characterized by massive enlargement of fluid-filled renal cysts.Progressively enlarging cysts compromise normal renal parenchyma,reduce renal function and lead to renal failure.Up to now,the treatment options for ADPKD have been limited to renal replacement therapy by dialysis or by transplantation for patients with end-stage renal failure.Inhibition of cyst fluid secretion,suppression of cyst epithelial cell growth and prevention of renal failure are new approaches to treat PKD.
