Clinical observation of capecitabine as first-line monotherapy in elderly patients with Ⅱa breast cancer
- VernacularTitle:卡培他滨单药一线治疗Ⅱa期老年乳腺癌的临床研究
- Author:
Wei HU
;
Junyi SHI
;
Yuan SHENG
;
Li LI
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
drug therapy;
capecitabine;
aged
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical effect and adverse reaction of capecitabine as first-line monotherapy in elderly patients with stage Ⅱa breast cancer.Methods:From June 2002 to June 2005,71 elderly patients with stage Ⅱa breast cancer received chemotherapy(different scheme:capecitabine group and CEF group) after operation.The efficacies and adverse reactions were evaluated and compared between the two groups.Results:The 3-year and 5-year survival rates of patients in capecitabine group were 97.06% and 94.12%,respectively; the relapse rate was 5.88%; all were comparable to those of CEF group. One of the advantages of capecitabine was its oral administration. The adverse effect of capecitabine was mainly hand-foot syndrome,with an incidence of 82.35%,but was tolerable. The gastrointestinal reaction and bone marrow repression in capecitabine group were significantly lower than those in the CEF group(P
