Correlation between rotavirus NSP1 and species restriction:a bioinformation study
- VernacularTitle:轮状病毒非结构蛋白1与种属限制性的相关性研究
- Author:
Kaijun LIU
;
Jintao LI
;
Kun WEI
;
Guan LIAN
- Publication Type:Journal Article
- Keywords:
rotavirus;
nonstructural protein 1;
species restriction;
interferon regulatory factor
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between rotavirus nonstructural protein 1(NSP1) and species restriction of the virus and explore the role of NSP1 in the species restriction.Methods NSP1 C-terminal sequences,its whole amino acid sequences from UniProt Database,and its 3' noncoding sequences from GenBank were collected,and intraspecies and interspecies sequence alignment and phylogenetic tree analysis were performed by DNAStar(Lasergene)7.1.Results The diversity of NSP1 between species and rotavirus species restriction hosted a high degree of consistency.NSP1 C-terminal sequence,NSP1 gene 3' noncoding sequence and NSP1 whole sequence shared a high intraspecies identity,which was higher than the identity between species(P
