Correlation between of G protein-coupled receptor kinases 4 polymorphism and essential hypertension:a Meta-analysis
- VernacularTitle:G蛋白激酶4基因多态性与高血压病相关性的Meta分析
- Author:
Weibin SHI
;
Changqing YU
;
Chunyu ZENG
- Publication Type:Journal Article
- Keywords:
G protein-coupled receptor kinases 4;
essential hypertension;
Meta analysis;
polymorphism
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To access the relationship between the polymorphism of G protein-coupled receptor kinases 4(GRK4,including R65L,A486V and A142V) and essential hypertension.Methods All the literature on the subjects was searched by keywords such as essential hypertension,hypertension,G protein-coupled receptor kinases 4 gene,and polymorphism in the electronic databases,Medline of Year 1997 to 2006.RevMan 4.2 software was used for Meta analysis.Results A total of 857 cases and 913 controls from 4 studies were included.The ORs of genotypes of R65L,A142V and A486V were 0.97(0.75 to 1.25,P=0.81),0.81(0.30 to 2.08,P=0.65) and 1.48(1.16 to 1.8,P=0.001) respectively.Conclusion GRK4 gene polymorphism A486V is significantly associated with susceptibility of essential hypertension.People who carries A486V have a higher risk to be subject to essential hypertension.
