Total body irradiation before hematopoietic blood stem cells transplantation:clinical analysis of 78 cases
- VernacularTitle:全身照射用于造血干细胞移植前预处理78例临床分析
- Author:
Dezhi LI
;
Yibing ZHOU
;
Jiuqing WAN
;
Zhengtang CHEN
- Publication Type:Journal Article
- Keywords:
total body irradiation;
blood stem cell transplantation;
malignant tumors in blood
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the efficacy,dose and complications of total body irradiation(TBI) for patients to receive hematopoietic stem cell transplantation(HSCT) in the treatment of leukemia and malignant lymphoma.Methods From May 2002 to February 2007,78 cases with leukemia or malignant lymphoma received the TBI before HSCT in our department.All the patients were irradiated with linear accelerator in 2 consecutive days at a total dose of 7 to 11 Gy,dose rate of 4.5 to 5.0 cGy/min,once per day.Among them,55 cases received traditional high-dose chemotherapy before radiotherapy,and the other 23 cases got TBI first followed by high-dose chemotherapy.Results All the cases used TBI prior to transplantation was successful,and no serious complication such as radiation pneumonitis was observed.Conclusion Our TBI regime is a safe and effective pretreatment for HSCT.TBI used before the large doses of the chemotherapy is recommended because it is proved to be effective,without affecting the survival rate,and of lesser TBI reaction and of lesser preparation work for irradiation to radiotherapist.More attention should be paid when the linear accelerator is employed for TBI.
