Effect of Age on Activity of Choline Enzyme in Cerebral Cholinergic Nerve System of Rat.
- VernacularTitle:年龄对大鼠大脑胆碱能神经系统胆碱酶活性的影响
- Author:
Haiying DONG
;
Guoliang GONG
;
Li ZHOU
;
Xiaojie ZHANG
- Publication Type:Journal Article
- Keywords:
Age;
Cholineacetyltransferase;
Acetylcholinesterase;
Chromatometry
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of age on activity of cholineacetyltransferase(ChAT) and acetylcholinesterase(AChE) in cerebral cholinergic nerve system of rat.Method According to age,male Sprague-Dawley rats were divided into the following 3 groups at random: 4～5 weeks old group,4～5 months old group,14～15 months old group(n=10,respectively).Chromatometry was used to assay the activity of ChAT and AChE in cerebral cortex,hippocampus and corpus striatum.Results In 14～15 months old rats,activity of ChAT and AChE in cerebral cortex,hippocampus and corpus striatum was prominantly reduced,as compared with that in 4～5 months old rats and in 4～5 weeks old rats(ChAT: P0.05).Conclusion There is a negative correlation between age and activity of ChAT and AChE in cerebral cholinergic nerve system.
