Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs.
10.4142/jvs.2016.17.1.123
- Author:
Yongsun KIM
1
;
Seung Hoon LEE
;
Wan Hee KIM
;
Oh Kyeong KWEON
Author Information
1. BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. ohkweon@snu.ac.kr
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
adipose derived mesenchymal stem cells;
decompression surgery;
dog;
intervertebral disc disease
- MeSH:
Acute Disease;
Adipose Tissue/cytology;
Animals;
Decompression, Surgical/veterinary;
Dog Diseases/*therapy;
Dogs;
Female;
Intervertebral Disc Degeneration/therapy/*veterinary;
Intervertebral Disc Displacement/therapy/*veterinary;
Male;
Mesenchymal Stem Cell Transplantation/*veterinary;
Pain Perception;
Treatment Outcome
- From:Journal of Veterinary Science
2016;17(1):123-126
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thirty-four dogs with no deep pain perception due to acute thoracolumbar intervertebral disc disease underwent decompression surgery within 1 week of diagnosis. All dogs underwent hemilaminectomy. Adipose derived mesenchymal stem cells (AD-MSCs) were transplanted into the injured spinal cord parenchyma for the AD-MSCs transplant dogs. Long-term outcome was evaluated at the end of the follow-up period (> 6 months). AD-MSCs combination treatment showed better recovery outcomes compared to decompression surgery alone. These results indicate that this stem cell therapy is a potential therapeutic strategy to overcome the limitations of treatment for spinal cord injury in clinical medicine.
