Effects of Rosiglitazone on Express of Nuclear Factor-kappa B in Peripheral Blood Mononuclear Cells of Multiple Organ Dysfunction Syndrome Rats.
- VernacularTitle:罗格列酮对MODS大鼠外周血单个核细胞内NF-?B表达的影响
- Author:
Wanhai QIAO
;
Jing WANG
;
Li QU
;
Liming WANG
- Publication Type:Journal Article
- Keywords:
Multiple organ dysfunction syndrome;
Peroxisome proliferators activated receptor?;
Nuclear factor-kappa B;
Rosiglitazone;
Peripheral blood mononuclear cell
- From:
Journal of Medical Research
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of rosiglitazone,an agonist of proliferators activated receptor?(PPAR?),on expression of nuclear factor-kappa B(NF-?B)in peripheral blood mononuclear cells(PBMC)of multiple organ dysfunction syndrome(MODS) rats.Methods Forty male SD rats were randomly divided into four groups(n = 6 per group): vehicle control group,endotoxin(LPS) group,rosiglitazone(ROSI) pretreatment group,and PPAR-?antagonist GW9662 pretreatment group.Blood was taken 4 hours after operation,and mononuclear cells were separated.The expression of NF-?B p65in PBMC was detected by immunocytochemical method and image analysis was carried out.Results The expression of NF-?B p65 was low in vehicle control group.In LPS group,the expression of NF-?B p65 was significantly higher than that in vehicle control group(P0.05).Conclusion Rosiglitazone protected the MODS rats by inhibiting NF-?B activation.
