Experimental study on relationship of Hyaluronic Acid and transforming growth factor-?_1 with different TCM syndromes of liver fibrosis
- VernacularTitle:肝纤维化不同证型与血清透明质酸、转化生长因子-?_1关系的实验研究
- Author:
Shan XU
;
Jianfeng BAO
;
Min ZHOU
;
Yongsheng ZHANG
- Publication Type:Journal Article
- Keywords:
Liver Fibrosis;
Hyaluronic Acid;
Transforming growth factor-?_1
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the relationship of Hyaluronic Acid and transforming growth factor-?1 with different TCM syndromes of liver fibrosis. Methods:All rats of model groups were treated by CCl4 to establish the liver fibrosis model. Besides CCl4,the rats of liver-stagnation and spleen-deficiency group were treated by stimulating tails with forceps clip and gastric infusion of rhubarb decoction,and the rats of qi-deficiency and blood-stasis group were treated by the method of swimming-fatigue. Then every group was intervened by the relevant medicine. After all treatments,the HA and TGF-?1 in serum were examined. Results:The HA and TGF-?1 of model groups were significantly higher than those of the control group(P
