Effects of Naotaifang extracts on expression of VEGF after focal cerebral ischemia in rats
- VernacularTitle:脑泰方提取物对局灶性脑缺血大鼠血管内皮生长因子表达的影响
- Author:
Yi CHEN
;
Guozuo WANG
;
Jinwen GE
- Publication Type:Journal Article
- Keywords:
Focal cerebral ischemia;
VEGF;
Naotaifang extract
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To approach the effect of Naotangfang extracts on expression of vascular endothelial growth factor(VEGF) after focal cerebral infarct in rats. Methods:30 Sprague-Dawley(SD) rats were randomly divided into 6 groups:sham operation group,model group,Naotaifang extract groups(low,middle,and high dosage) ,and Naofukang group. Some indexes were detected such as neurological scores,VEGF mRNA expression by RT-PCR,and the number of VEGF positive cells by immunohistochemical methods. Results:The symptoms in nervous function were improved in the Admin. groups,especially in the Naotaifang middle dosage group. The number of VEGF positive cells and VEGF PCR production in Naotaifng middle dosage group was higher than that in the model group. Conclusion:Naotaifang has neuroprotective effect against focal cerebral ischemic injury by improving the expression of VEGF.
