Comparative study on dissolution of strychnine in normal and ultra-micro powder of semen strychi
- VernacularTitle:马钱子超微粉体和常规粉体中马钱子碱的溶出比较
- Author:
Long ZOU
;
Hui GUI
;
Shichao HUANG
;
Guangxian CAI
;
Zhengping TANG
- Publication Type:Journal Article
- Keywords:
Semen strychi;
Ultra-micro powder;
Normal powder;
Strychnine;
Vitro dissolution
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Dissolution test was applied to study the dissolution rates of strychnine from the normal and ultramicro powder of semen strychi. Methods:HPLC techniques was used to detect the dissolution amount and the dissolution velocity of strychnine from the normal and ultra-micro powder of semen strychi. Results:The dissolution velocity of strychnine from the ultra-micro powder was higher than that from the normal powder,but there was no difference in the dissolution amount 4 hours later. Conclusion:The dissolution velocity of strychnine from the ultra-micro powder increased greatly and there was no loss of the principal active.
