Effect of Kangxianyixin prescription on cardiocyte apoptosis and expression of Bax and Bcl-2 in rRats with dilated cardiomyopathy
- VernacularTitle:抗纤益心方对扩张型心肌病大鼠心肌细胞凋亡及Bax、Bcl-2蛋白表达的影响
- Author:
Zhentao WANG
;
Lihua HAN
;
Mingjun ZHU
;
Chenghao CAO
;
Songbo CAI
- Publication Type:Journal Article
- Keywords:
Kangxianyixin prescription;
Dilated cardiomyopathy;
Cardiocyte apoptosis;
Experiment research
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To expound the effect of Kangxianyixin prescription on cardiocyte apoptosis and expression of Bax and Bcl-2 in rats with dilated cardiomyopathy. Methods:Wistar rats with dilated cardiomyopathy established by furazolidone were treated 8 weeks with Kangxianyixin prescription,to observe cardiocyte apoptosis and to measure Bax and Bcl-2 expression in rats. Results:(1) In comparison of cardiomyocyte apoptosis indexes in rats,when compared with model group,the results showed significant difference in the combined group of high dosage of Kangxianyixin prescription and captopril,the high dosage group,the low dosage group,the captopril group(P
