A systematic review of eradicating helicobacter pylori with ranitidine bismuth citrate
- VernacularTitle:以枸橼酸铋雷尼替丁为基础的三联疗法根除幽门螺杆菌的系统评价
- Author:
Fandong MENG
;
Shutian ZHANG
;
Qiaozhi ZHOU
;
Zhonglin YU
- Publication Type:Journal Article
- Keywords:
ranitidine bismuth citrate;
helicobacter pylori;
meta-analysis
- From:
Chinese Journal of Practical Internal Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the Helicobacter pylori eradication efficacy with ranitidine bismuth citrate(RBC) and two antibiotics,and to conduct a meta-analysis of randomized clinical trials comparing the efficacy of proton pump inhibitor(PPI)vs RBC with two antibiotics for 1 week.Methods Selection of studies:studies evaluating RBC plus two antibiotics were considered.For the meta-analysis,randomized controlled trials comparing PPI vs.RBC plus two antibiotics for 1 week were included.Data Source:RCTs were identified from CBM,handsearching,and personal contact with pharmaceutical companies.Inclusion criteria:data were extracted independently by two reviewers.The methodological quality of trials was assessed by the Jadad-scale.Statistics analysis was managed by using RevMan 4.2.Results Twelve randomized clinical trials including 1254 patients were included.The meta-analysis showed comparable efficacy with RBC and PPI (OR=1.30,95% CI:0.94～1.81,P=0.12).Conclusion The efficacy of RBC and PPI-based triple regimens were comparable.
