Relationship between serum or urine TIMP-1 levels and the stages of CKD
- VernacularTitle:慢性肾脏病金属蛋白酶组织抑制剂-1和临床分期关系的研究
- Author:
Jie FENG
;
Hongli LIN
;
Hua XIE
;
Keping WANG
;
Yanling SUN
;
Lu WANG
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
tissue inhibitor of metalloproteinases-1;
glomerular filtration rate;
renal fibrosis
- From:
Chinese Journal of Practical Internal Medicine
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum or urine tissue inhibitor of metalloproteinases-1 (TIMP-1)levels and the stages of chronic kidney disease (CKD).Methods Serum and urine level of TIMP-1 were measured by enzyme-linked immunoadsorbent assay (ELISA) in 122 CKD patients and 40 healthy controls.Serum cystatin-C (CystC),parathyroid hormone (PTH),low-density lipoprotein (LDL)and other markers were determined simultaneously.Correlationanalysis between TIMP-1 level and degree of renal function were performed.Results Serum and urine TIMP-1 of the patients in CKD group was significantly higher than that in control group (P
